RNAi misses the target

Current efforts in the analysis of RNAi and RNAi target genes

RNAi is RNA interference by short RNAs. It influences gene-expression by down-regulation of mRNAs, typically by complementarity to the 3' UTR (untranslated region) of the mRNA. microRNAs (miRNAs) are short RNAs acting as natural RNAi. miRNAs mediate down-regulation of many mRNAs from developmental genes and transcription factor genes. Natural examples for this additional level of post-transcrip...

Off-Target Effects: Disturbing the Silence of RNA interference (RNAi)

Figure 1. Small RNA molecules, miRNA and siRNA, regulate mRNA translation through RNA interference (RNAi). Depending on the level of complementarity between the small RNA molecule and mRNA, the mRNA will be silenced (complete) or translationally repressed (partial). siRNA off-targeting effects occur through partial complementarity of the siRNA with unintended mRNA targets. Since the discovery t...

Noakes misses the point.

the impact of skopos on syntactic features of the target text

the present study is an experimental case study which investigates the impacts, if any, of skopos on syntactic features of the target text. two test groups each consisting of 10 ma students translated a set of sentences selected from advertising texts in the operative and informative mode. the resulting target texts were then statistically analyzed in terms of the number of words, phrases, si...

CD22ΔE12 as a molecular target for RNAi therapy.

B-precursor acute lymphoblastic leukaemia (BPL) is the most common form of cancer in children and adolescents. Our recent studies have demonstrated that CD22ΔE12 is a characteristic genetic defect of therapy-refractory clones in paediatric BPL and implicated the CD22ΔE12 genetic defect in the aggressive biology of relapsed or therapy-refractory paediatric BPL. The purpose of the present study i...